| Primary Identifier | MGI:2680903 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Sod1 |
| Transmission | Germline | Strain of Origin | C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A genomic fragment containing most of exon 3 and all of exon 4 was replaced with a promoterless neomycin selection gene. A shortened transcript is expressed from this allele that splices exon 2 to exon 5. A 50% reduction in protein activity was demonstrated in tissues of heterozygous mice. Additional genetic studies and FISH analysis indicated that a duplication and translocation of flanking sequences to a different chromosome had taken place. See also Ts(12<16>)1Cje. |
