| Primary Identifier | MGI:96604 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 16402 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables integrin binding activity. Involved in regulation of angiogenesis. Acts upstream of or within several processes, including cell-cell adhesion mediated by integrin; cell-substrate junction assembly; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and genitourinary system. Orthologous to human ITGA5 (integrin subunit alpha 5). PHENOTYPE: Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
