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Protein Coding Gene : Zpbp zona pellucida binding protein
Primary Identifier  MGI:1855701 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  53604
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Acts upstream of or within acrosome assembly and binding activity of sperm to zona pellucida. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human ZPBP (zona pellucida binding protein).
PHENOTYPE: Male mice homozygous for a null mutation display infertility and asthenoglobozoospermia. Heterozygous males display an increase in the percentage of abnormal sperm. [provided by MGI curators]
  • synonyms:
  • MGI:1922227,
  • Zpbp,
  • Sp38,
  • RIKEN cDNA 4930486K01 gene,
  • zona pellucida binding protein,
  • 4930486K01Rik
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