| First Author | Ettaiche M | Year | 2004 |
| Journal | J Neurosci | Volume | 24 |
| Issue | 5 | Pages | 1005-12 |
| PubMed ID | 14762118 | Mgi Jnum | J:90117 |
| Mgi Id | MGI:3042539 | Doi | 10.1523/JNEUROSCI.4698-03.2004 |
| Citation | Ettaiche M, et al. (2004) Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci 24(5):1005-12 |
| abstractText | pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity. |
