| First Author | Podrini C | Year | 2013 |
| Journal | Mamm Genome | Volume | 24 |
| Issue | 5-6 | Pages | 240-51 |
| PubMed ID | 23712496 | Mgi Jnum | J:199109 |
| Mgi Id | MGI:5500855 | Doi | 10.1007/s00335-013-9456-0 |
| Citation | Podrini C, et al. (2013) High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice. Mamm Genome 24(5-6):240-51 |
| abstractText | C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J genome, is versatile in a wide range of phenotyping and experimental settings and large repositories of B6N ES cells have been developed. Here, we present a series of studies showing the baseline characteristics of B6N fed a high-fat diet (HFD) for up to 12 weeks. We show that HFD-fed B6N mice show increased weight gain, fat mass, and hypercholesterolemia compared to control diet-fed mice. In addition, HFD-fed B6N mice display a rapid onset of lipid accumulation in the liver with both macro- and microvacuolation, which became more severe with increasing duration of HFD. Our results suggest that the B6N mouse strain is a versatile background for studying diet-induced metabolic syndrome and may also represent a model for early nonalcoholic fatty liver disease. |
