| First Author | Andria ML | Year | 1991 |
| Journal | J Immunol | Volume | 147 |
| Issue | 3 | Pages | 1030-6 |
| PubMed ID | 1650385 | Mgi Jnum | J:11355 |
| Mgi Id | MGI:59791 | Doi | 10.4049/jimmunol.147.3.1030 |
| Citation | Andria ML, et al. (1991) Genomic organization and chromosomal localization of the TAPA-1 gene. J Immunol 147(3):1030-6 |
| abstractText | TAPA-1 is a 26-kDa integral membrane protein expressed on many human cell types. Antibodies against TAPA-1 induce homotypic aggregation of cells and can inhibit their growth. The murine homologue of TAPA-1 was cloned from both cDNA and genomic DNA libraries. A very high level of homology was found between human and mouse TAPA-1. The 5' untranslated region of the TAPA-1 gene resembles housekeeping gene promoters with respect to G + C content and the presence of potential Sp1 binding sites. The chromosomal localization of human and murine TAPA-1 genes was determined by Southern blot experiments using DNA from somatic cell hybrids. The genes were found to be part of a conserved syntenic group in mouse chromosome 7 and the short arm of human chromosome 11. The organization of the TAPA-1 gene and the projection of the exon boundaries on the proposed protein structure are presented. |
