| First Author | Hillebrandt S | Year | 1996 |
| Journal | Mutat Res | Volume | 372 |
| Issue | 1 | Pages | 43-51 |
| PubMed ID | 9003530 | Mgi Jnum | J:37526 |
| Mgi Id | MGI:84918 | Doi | 10.1016/S0027-5107(96)00109-1 |
| Citation | Hillebrandt S, et al. (1996) Genetic analysis of the cause of gastroschisis in the HLG mouse strain. Mutat Res 372(1):43-51 |
| abstractText | An inbred mouse strain HLG shows a high incidence of gastroschisis after X-ray exposure to the zygotes. About 11% of the fetuses display this malformation after irradiation with 1 Gy. The C57BL-strain does not show the increased frequency of gastroschisis after radiation-exposure to the zygotes. The genetic background of this malformation was investigated in a backcross of HLG x C57BL females to HLG males. The pregnant HLG x C57BL females were irradiated in a stage in which the (HLG x C57BL) x HLG [BC1] embryos were in the 1-cell stage. The frequency of gastroschisis in the BC1 generation was compared with a genetic model of a single recessive mutation with 11% penetrance. This frequency does not fit a single-locus inheritance. The number of loci involved was estimated to be about two or three. HLG mouse strain may be a valuable animal model in the study of polygenic traits. |
