| First Author | Raja KB | Year | 1995 |
| Journal | Br J Haematol | Volume | 89 |
| Issue | 1 | Pages | 177-80 |
| PubMed ID | 7833260 | Mgi Jnum | J:23013 |
| Mgi Id | MGI:70646 | Doi | 10.1111/j.1365-2141.1995.tb08926.x |
| Citation | Raja KB, et al. (1995) Plasma clearance of transferrin in control and hypotransferrinaemic mice: implications for regulation of transferrin turnover. Br J Haematol 89(1):177-80 |
| abstractText | Kinetic studies were performed to determine the clearance of iodinated transferrin in hypotransferrinaemic mice, as compared to normal animals. Clearance of i.v. (and i.p.) administered radiolabelled protein in homozygous (hpx/hpx) mice was significantly faster than in heterozygous (hpx/+) and wild-type control (+/+) groups. A comparable t1/2 value for transferrin clearance in hpx/hpx mice was derived from a study in which immunoassay was performed on serum samples obtained at various times post-injection with normal mouse serum, indicating that the clearance of 125I reflected true clearance of transferrin protein. The clearance rate in the hpx/+ group was significantly slower than in +/+ mice. Calculation of transferrin synthesis rates in these two groups suggested that transferrin levels do not regulate transferrin synthesis rates, but may affect degradation; this observation is consistent with the fact that transferrin levels in hpx/+ mice are > 50% of the values in +/+ mice, and indicates a partial compensation for reduced synthesis. The rapid clearance in hpx/hpx mice is an additional factor in determining the low levels of circulating transferrin in these synthesis-impaired mutants. |
