| First Author | Hiraki Y | Year | 1991 |
| Journal | Biochem Biophys Res Commun | Volume | 175 |
| Issue | 3 | Pages | 971-7 |
| PubMed ID | 1709014 | Mgi Jnum | J:54632 |
| Mgi Id | MGI:1335630 | Doi | 10.1016/0006-291x(91)91660-5 |
| Citation | Hiraki Y, et al. (1991) Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Biochem Biophys Res Commun 175(3):971-7 |
| abstractText | Here we report the structure and bioactivity of 25 kDa glycoprotein (chondromodulin-I) as a tissue-specific functional matrix component identified and cloned for the first time. Chondromodulin-I purified from fetal bovine cartilage markedly stimulated DNA synthesis of cultured growth-plate chondrocytes in the presence of basic fibroblast growth factor (FGF). Bovine chondromodulin-I cDNA revealed that the mature protein consists of 121 amino acids with three possible glycosylation sites and is coded as the C-terminal part of a larger precursor. On northern blot analysis, expression of chondromodulin-I mRNA was observed only in cartilage. |
