| First Author | Lee Y | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 10 | Pages | 1137-9 |
| PubMed ID | 18758459 | Mgi Jnum | J:140992 |
| Mgi Id | MGI:3815226 | Doi | 10.1038/nn.2183 |
| Citation | Lee Y, et al. (2008) miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat Neurosci 11(10):1137-9 |
| abstractText | Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. Here we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enhanced the cytotoxicity of polyglutamine-expanded ATXN1 in human cells. We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to protein dosage. |
