| Primary Identifier | MGI:4430218 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Celsr1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site and a neo cassette within intron 25 and an additional loxP site within intron 29 were added by homologous recombination. Cre-mediated recombination removed the floxed region. Translation of the mutant mRNA is predicted to produce a truncated protein with a scrambled sequence of 15 amino acids and a premature stop. Quantitative RT-PCR showed that transcript level was five fold lower in the mutant than in the wild-type. |
