| Primary Identifier | MGI:1914144 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 66894 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Involved in negative regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body size, domed skull, short snout, twisted snout and overgrown mandibular incisors. Mice homozygous for a different knock-out allele exhibit increased sensitivity to pIpC-treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
