| Primary Identifier | IPR017252 | Type | Family |
| Short Name | Dynein_regulator_LIS1 |
| description | This entry represents Lissencephaly-1 (LIS1) and homologues. LIS1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. They appear to regulate the mechanical behaviour of cytoplasmic dynein, the primary minus-end-directed microtubule motor []. Proteins in this entry include:Platelet-activating factor acetylhydrolase IB subunit alpha, also known as Lissencephaly-1 protein [].Nuclear distribution protein PAC1 from budding yeasts []. Fungal nuclear distribution protein nudF [, ].Mutations in the LIS1 gene cause Lissencephaly-1, a classical lissencephaly characterised by agyriaor pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex []. |
