| First Author | Kraig E | Year | 1996 |
| Journal | J Neuroimmunol | Volume | 71 |
| Issue | 1-2 | Pages | 87-95 |
| PubMed ID | 8982107 | Mgi Jnum | J:38176 |
| Mgi Id | MGI:85565 | Doi | 10.1016/s0165-5728(96)00151-8 |
| Citation | Kraig E, et al. (1996) Restricted T cell receptor repertoire for acetylcholine receptor in murine myasthenia gravis. J Neuroimmunol 71(1-2):87-95 |
| abstractText | Immunization of C57BL/6 mice with AChR provokes symptoms similar to those seen in the disease myasthenia gravis. To elucidate the structural requirements for T cell recognition of AChR and to identify TcR features which might provide targets for immunotherapy, a panel of T cell hybridomas was generated after immunization of mice with the immunodominant peptide of the AChR alpha chain. The TcR genes expressed by these hybridomas were sequenced. TcR-V beta 6 was preferentially employed, but other V beta genes were also observed. A conserved acidic residue was present in all CDR3 regions, regardless of the V beta. The TcR-V alpha repertoire was somewhat skewed with three V alpha families accounting for 82% of the sequences. The utilization of multiple T cell receptor V beta genes may contribute to the inability to inhibit EAMG by elimination of V beta 6+ T cells. |
