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Protein Coding Gene : Dnase2a deoxyribonuclease II alpha

Primary Identifier  MGI:1329019 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  13423
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables deoxyribonuclease II activity. Acts upstream of or within DNA catabolic process; enucleate erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Is expressed in liver; olfactory epithelium; and vibrissa. Used to study rheumatoid arthritis. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal).
PHENOTYPE: Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis. [provided by MGI curators]
  • synonyms:
  • Dnase2,
  • deoxyribonuclease II alpha,
  • Dnase2a,
  • deoxyribonuclease II

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For