| First Author | Sanchez Y | Year | 1995 |
| Journal | Bioessays | Volume | 17 |
| Issue | 6 | Pages | 545-8 |
| PubMed ID | 7575496 | Mgi Jnum | J:26243 |
| Mgi Id | MGI:73904 | Doi | 10.1002/bies.950170611 |
| Citation | Sanchez Y, et al. (1995) Stopped for repairs. Bioessays 17(6):545-8 |
| abstractText | The tumor suppressor protein p53 is intimately involved in the cellular response to DNA damage, controlling cell cycle arrest, apoptosis and the transcriptional induction of DNA damage inducible genes. A transcriptional target of p53, Gadd45, was recently found to bind to PCNA, a component of DNA replication/repair complexes, thereby implicating Gadd45 in DNA metabolism. Using biochemical assays, a role for Gadd45 in excision repair in vitro has been demonstrated. Antisense experiments have also indicated an in vivo role for the GADD45 gene in UV-irradiation survival. These discoveries establish a link between p53 and DNA repair through Gadd45. |
