| Primary Identifier | MGI:104579 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 16161 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Contributes to cytokine binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; positive regulation of activated T cell proliferation; and positive regulation of defense response to virus by host. Located in external side of plasma membrane. Part of interleukin-23 receptor complex. Is expressed in craniocervical region bone; male reproductive gland or organ; and rib. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
