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Comment :

Type  MGI:General Description  mutants become active ~ 2 hours before lights-off (start of dark cycle) while wild-type mice show activity at onset of dark period after LD entrainment for 3 weeks, exposure to a light pulse late in the dark phase followed by release into total darkness results in a phase advance of 6.8 hours compared to 1.8-2 hours exhibited by wild-type and heterozygotes in the same paradigm