Primary Identifier | MGI:96932 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 109904 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and dendrite development. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Is expressed in femur; fibula; and tibia. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence). PHENOTYPE: Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons. [provided by MGI curators] |