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Allele : Slc8a1<em1Motto> solute carrier family 8 (sodium/calcium exchanger), member 1; endonuclease-mediated mutation 1, Michela Ottolia
Primary Identifier  MGI:7643600 Allele Type  Endonuclease-mediated
Gene  Slc8a1 Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  Lysine codon 261 (AAG) in exon 1 was changed to glutamine (CAG) (p.K261Q) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks the Na+-dependent inactivation of the encoded peptide.
  • mutations:
  • Single point mutation
  • synonyms:
  • NCX1 K229Q,
  • NCX1 K229Q
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

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Trail: Allele




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