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Protein Coding Gene : Hikeshi heat shock protein nuclear import factor
Primary Identifier  MGI:96738 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  67669
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Acts upstream of or within Golgi organization and lung development. Located in cytoplasm. Is expressed in several structures, including adrenal gland; heart; intestine; liver; and respiratory system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi).
PHENOTYPE: Mice homozygous for an ENU-induced mutation die prenatally or neonatally, and exhibit cyanoisis with a significant emphysematous phenotype at birth. The secretory apparatus in Clara cells is also affected. [provided by MGI curators]
  • synonyms:
  • MGI:1913365,
  • heat shock protein nuclear import factor,
  • l7Rn6,
  • 1110002N09Rik,
  • 0610007P06Rik,
  • l(7)6Rn,
  • MGD-MRK-11694,
  • lethal, Chr 7, Rinchik 6,
  • MGI:1914919,
  • MGD-MRK-11726,
  • Hikeshi,
  • RIKEN cDNA 0610007P06 gene,
  • RIKEN cDNA 1110002N09 gene
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