| First Author | Baertsch NA | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 843 |
| PubMed ID | 29483589 | Mgi Jnum | J:260735 |
| Mgi Id | MGI:6149437 | Doi | 10.1038/s41467-018-03223-x |
| Citation | Baertsch NA, et al. (2018) The interdependence of excitation and inhibition for the control of dynamic breathing rhythms. Nat Commun 9(1):843 |
| abstractText | The preBotzinger Complex (preBotC), a medullary network critical for breathing, relies on excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBotC neurons are inhibitory, and the role of inhibition in rhythmogenesis remains controversial. Using optogenetics and electrophysiology in vitro and in vivo, we demonstrate that the intrinsic excitability of excitatory neurons is reduced following large depolarizing inspiratory bursts. This refractory period limits the preBotC to very slow breathing frequencies. Inhibition integrated within the network is required to prevent overexcitation of preBotC neurons, thereby regulating the refractory period and allowing rapid breathing. In vivo, sensory feedback inhibition also regulates the refractory period, and in slowly breathing mice with sensory feedback removed, activity of inhibitory, but not excitatory, neurons restores breathing to physiological frequencies. We conclude that excitation and inhibition are interdependent for the breathing rhythm, because inhibition permits physiological preBotC bursting by controlling refractory properties of excitatory neurons. |
