| First Author | Sugai M | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 1 | Pages | 25-30 |
| PubMed ID | 12483209 | Mgi Jnum | J:82963 |
| Mgi Id | MGI:2656384 | Doi | 10.1038/ni874 |
| Citation | Sugai M, et al. (2003) Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol 4(1):25-30 |
| abstractText | Serum concentrations of immunoglobulin E (IgE) in normal circumstances are kept much lower than those of other Ig isotypes to avoid allergic reactions. B cells lacking Id2 have increased E2A activity, which leads to specific enhancement of germline transcription of the immunoglobulin epsilon locus. As a consequence, Id2-deficient B cells undergo class switch recombination (CSR) to IgE at a much higher frequency than wild-type B cells. In contrast, Id2 is induced in wild-type B cells by transforming growth factor-beta1 (TGF-beta1) and suppresses IgE CSR. Our results provide evidence for the inhibitory and selective role of Id2 in IgE CSR in response to TGF-beta1. Id2 might act as molecular safeguard to suppress IgE CSR to prevent serious complications such as allergic hypersensitivity during the normal course of immune responses. |
