| Primary Identifier | MGI:1890494 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 114128 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Predicted to be located in several cellular components, including endosome; lysosome; and plasma membrane. Predicted to be active in lysosomal membrane. Is expressed in several structures, including central nervous system; incisor; liver; retina; and submandibular gland primordium. Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). PHENOTYPE: Homozygous knockout affects cardiomyocyte cell death, leading to exacerbation of ischemia-induced cardiac infarction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
