| Primary Identifier | MGI:3528894 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Thy1-SNCA*A53T)9813Putt |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| description | Line 9956, which expresses the transgene product at a lower level than line 9813, was also produced. Transgenic mice express human A53T variant alpha-synuclein under the direction of the mouse Thy1 promoter. These mice display axonal degeneration in spinal roots, denervation of neuromuscular junctions, inclusions and reactive gliosis in spinal cord and brainstem, and decrease in rotarod performance after 40 days of age. |
| molecularNote | The transgene contains mouse Thy1 promoter sequences and 396 bp of human alpha synuclein cDNA encoding an Ala53Thr mutation. Immunoblot studies detected transgene expression in brain homogenates of transgenic mice. |
