| Primary Identifier | MGI:96925 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 17196 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables calmodulin binding activity and protease binding activity. Acts upstream of or within several processes, including myelination; response to toxic substance; and sensory perception of sound. Located in several cellular components, including compact myelin; internode region of axon; and neuronal cell body. Part of protein-containing complex. Is expressed in several structures, including central nervous system; hemolymphoid system; lung; nose; and peripheral nervous system. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein). PHENOTYPE: Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
