| Type | MGI:General | Description | homozygotes exhibit increased susceptibility to invasive pulmonary aspergillosis (IPA), with a median survival time of 3 days, and a significant increase in lung and brain colonization; in contrast, all wild-type control mice survive infection in an IPA model of allogeneic, T-cell-depleted bone marrow transplantation, combined systemic and local PTX3 administration results in a 2-fold increase in survival time with 2 of 8 homozygotes being cured, along with a >4-fold reduction in lung CFU counts |
