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Protein Coding Gene : Nr2c1 nuclear receptor subfamily 2, group C, member 1

Primary Identifier  MGI:1352465 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  22025
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid receptor signaling pathway. Located in PML body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1).
PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in testis development or in spermatogenesis; no gross defects were detected in the central nervous system and normal motor neuron cell numbers were noted. [provided by MGI curators]
  • synonyms:
  • TR2,
  • Tr2-11,
  • MGI:2443924,
  • Eenr,
  • early embryonic nuclear receptor,
  • RIKEN cDNA 4831444H07 gene,
  • orphan receptor, TR2-11,
  • MGI:104613,
  • nuclear receptor subfamily 2, group C, member 1,
  • Nr2c1,
  • MGD-MRK-26100,
  • MGI:104660,
  • 4831444H07Rik,
  • MGD-MRK-26050

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For