Primary Identifier | MGI:1913094 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Myog |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A hypomorphic allele was generated by the insertion of a full length myogenin cDNA followed by an SV40 T polyadenylation site and a loxP-flanked neomycin cassette into the first exon and deletion of basepairs +48 to +511. Transcript was present at approximately one-fourth the level of controls in muscle. The mutant genomic sequence still contains the transcription start site and the splice donor of the first exon. |