| Primary Identifier | MGI:894762 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 16825 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including LIM domain binding activity; protein homodimerization activity; and transcription coactivator activity. Contributes to DNA binding activity. Involved in several processes, including negative regulation of erythrocyte differentiation; positive regulation of macromolecule biosynthetic process; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; epithelial structure maintenance; and hair follicle development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; eye; and genitourinary system. Used to study nail-patella syndrome. Orthologous to human LDB1 (LIM domain binding 1). PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
