| First Author | Lalfer M | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 521 | PubMed ID | 30941146 |
| Mgi Jnum | J:294672 | Mgi Id | MGI:6457162 |
| Doi | 10.3389/fimmu.2019.00521 | Citation | Lalfer M, et al. (2019) Foxp3(+) Regulatory and Conventional CD4(+) T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells. Front Immunol 10:521 |
| abstractText | Foxp3(+) regulatory T cells (Tregs) play a major role in acquired immune tolerance to allogenic transplants. Their suppressive activity is thought to require T cell receptor (TCR)-driven antigen recognition; little, however, is known about the fraction of Tregs able to recognize alloantigens within this T cell subset primarily educated against self-antigens. Performing transfer experiments of Tregs or conventional T cells (Tconv) into both lymphoreplete and lymphopenic mice, we observed a similarly high proportion of cells signaling through their TCR and proliferating in allogenic hosts. Furthermore, using an in vivo proliferation assay with limited T cell numbers infused into lymphopenic mice, we found that the overall frequency of alloreactive Tregs was similar if not higher to that of alloreactive Tconv. Overall our study highlights a noticeably high level of alloreactive Foxp3(+) regulatory T cells accounting for their predominant role in transplantation tolerance. |
