| Primary Identifier | MGI:1890358 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 319765 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and translation regulator activity, nucleic acid binding. Involved in negative regulation of translation. Acts upstream of or within cold-induced thermogenesis and energy homeostasis. Predicted to be located in P-body; cytoplasmic stress granule; and cytoskeleton. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adipose tissue; early conceptus; future spinal cord; gonad; and otocyst. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased resistance to diet-induced obesity, decreased susceptibility to induced hypothermia and increased uncoupled oxygen consumption in adipocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
