| First Author | Ryseck RP | Year | 1992 |
| Journal | Mol Cell Biol | Volume | 12 |
| Issue | 2 | Pages | 674-84 |
| PubMed ID | 1732739 | Mgi Jnum | J:22332 |
| Mgi Id | MGI:70211 | Doi | 10.1128/mcb.12.2.674 |
| Citation | Ryseck RP, et al. (1992) RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol 12(2):674-84 |
| abstractText | We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa B sites, but heterodimers between RelB and p50-NF-kappa B do bind to different NF-kappa B-binding sites with a similar affinity to that shown by p50-NF-kappa B homodimers. However, RelB/p50-NF-kappa B heterodimers, in contrast to p50-NF-kappa B homodimers, transactivate transcription of a promoter containing a kappa B-binding site. |
