| Primary Identifier | MGI:96819 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 16952 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including double-stranded DNA helicase activity; phospholipase A2 inhibitor activity; and phospholipid binding activity. Predicted to contribute to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; neutrophil homeostasis; and positive regulation of neutrophil apoptotic process. Acts upstream of or within several processes, including arachidonic acid secretion; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; lateral plasma membrane; and sarcolemma. Is active in cornified envelope. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; skeleton; and trophectoderm. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). PHENOTYPE: Mutations in this gene result in increased inflammatory response and decreased macrophage activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
