| Primary Identifier | MGI:104778 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 18797 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including calmodulin binding activity; molecular function activator activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within regulation of systemic arterial blood pressure. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3). PHENOTYPE: Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
