| Primary Identifier | MGI:4437471 | Allele Type | Transgenic |
| Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(Myh6*/tetO-Capn1)L1Gwd |
| Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | These MHCminTetO-Capn1 transgenic mice were generated by inserting the entire coding region of the mouse Calpain 1 gene into an MHCminTetO-promoter construct. The expression of this construct was driven by a mouse alpha-myosin heavy chain (alpha-MHC; Myh6) promoter under control of a tetracycline operator (tetO), followed by a human growth hormone polyadenylation (polyA) signal. This construct also contained 3 altered GATA sites and 2 altered thyroid-like response elements (TRE) maintaining low levels of cardiac-specific expression and decreased background. Three lines were created (L1, L2, and L3) with ascending levels of expression. |
