| First Author | Saito K | Year | 2011 |
| Journal | Nucleic Acids Res | Volume | 39 |
| Issue | 14 | Pages | 6086-99 |
| PubMed ID | 21486751 | Mgi Jnum | J:182956 |
| Mgi Id | MGI:5317236 | Doi | 10.1093/nar/gkr194 |
| Citation | Saito K, et al. (2011) MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6. Nucleic Acids Res 39(14):6086-99 |
| abstractText | The transcription factor HIF-1alpha (hypoxia inducible factor 1alpha) has an essential role in the maintenance of oxygen homeostasis in metazoans. HIF-1alpha expression and activity in the hypoxic response is regulated at the translation and post-translational levels. However, the mechanism and modulator of HIF-1alpha translation during hypoxia is not fully understood. We found that HIF-1alpha expression during hypoxia was upregulated by the microRNA 130 (miR-130) family. Levels of the miR-130 family are elevated under hypoxia, and their target is DDX6 mRNA, which is a component of the P-bodies. Furthermore, we found that a decrease of DDX6 expression by the miR-130 family enhanced the translation of HIF-1alpha in an internal ribosome entry site element-dependent manner. These results reveal a new HIF-1alpha translational mechanism and a role for P-bodies in hypoxic stress. |
