| First Author | Daly JW | Year | 1994 |
| Journal | Brain Res | Volume | 650 |
| Issue | 1 | Pages | 153-6 |
| PubMed ID | 7953667 | Mgi Jnum | J:19111 |
| Mgi Id | MGI:67312 | Doi | 10.1016/0006-8993(94)90219-4 |
| Citation | Daly JW, et al. (1994) Chronic effects of ethanol on central adenosine function of mice. Brain Res 650(1):153-6 |
| abstractText | Chronic ingestion of 5% ethanol had no significant effect on open field locomotor of NIH Swiss strain male mice, nor were the depressant effects of a non-selective adenosine receptor agonist, NECA, or the stimulant effects of a non-selective antagonist, caffeine significantly altered. The density of cerebral cortical A1-adenosine receptors and of nitrendipine binding sites on calcium channels were significantly increased after chronic ethanol, while the density of striatal A2a-adenosine receptors were unchanged. The locomotor stimulant effects of ethanol (2.5 g/kg) were slightly decreased after chronic ethanol, but were markedly reduced in mice after chronic caffeine ingestion. The results suggest some involvement of adenosine systems in the effects of ethanol. |
