| Primary Identifier | MGI:2181667 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 170770 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ATPase binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of apoptotic process. Acts upstream of or within cellular response to ionizing radiation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and positive regulation of apoptotic process. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Orthologous to human BBC3 (BCL2 binding component 3). PHENOTYPE: Mice homozygous for disruptions in this gene display abnormalities in apoptosis but otherwise are phenotypically normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
