| First Author | Dong C | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 6 | Pages | 3659-62 |
| PubMed ID | 11238604 | Mgi Jnum | J:126655 |
| Mgi Id | MGI:3761786 | Doi | 10.4049/jimmunol.166.6.3659 |
| Citation | Dong C, et al. (2001) Cutting edge: critical role of inducible costimulator in germinal center reactions. J Immunol 166(6):3659-62 |
| abstractText | Inducible costimulator (ICOS) is a new member of the CD28/CTLA-4 family that is expressed on activated and germinal center (GC) T cells. Recently, we reported that ICOS-deficient mice exhibited profound defects in T cell activation and effector function. Ab responses in a T-dependent primary reaction and in a murine asthma model were also diminished. In the current study, we investigate the mechanism by which ICOS regulates humoral immunity and examine B cell GC reactions in the absence of ICOS. We found that ICOS(-/-) mice, when immunized with SRBC, had smaller GCs. Furthermore, IgG1 class switching in the GCs was impaired. Remarkably, GC formation in response to a secondary recall challenge was completely absent in ICOS knockout mice. These data establish a critical role of ICOS in regulation of humoral immunity. |
