| First Author | Tsukamoto S | Year | 2009 |
| Journal | Expert Opin Ther Targets | Volume | 13 |
| Issue | 5 | Pages | 605-21 |
| PubMed ID | 19397479 | Mgi Jnum | J:148773 |
| Mgi Id | MGI:3846474 | Doi | 10.1517/14728220902866851 |
| Citation | Tsukamoto S, et al. (2009) Targeting the proteasome pathway. Expert Opin Ther Targets 13(5):605-21 |
| abstractText | BACKGROUND: The ubiquitin-proteasome pathway functions as a main pathway in intracellular protein degradation and plays a vital role in almost all cellular events. Various inhibitors of this pathway have been developed for research purposes. The recent approval of bortezomib (PS-341, Velcade, a proteasome inhibitor, for the treatment of multiple myeloma has opened the way to the discovery of drugs targeting the proteasome and other components of the ubiquitin-proteasome pathway. OBJECTIVES: We review the current understanding of the ubiquitin-proteasome pathway and inhibitors targeting this pathway, including proteasome inhibitors, as candidate drugs for chemical therapy. METHODS: Preclinical and clinical data for inhibitors of the proteasome and the ubiquitin-proteasome pathway are discussed. CONCLUSIONS: The proteasome and other members in the ubiquitin-proteasome pathway have emerged as novel therapeutic targets. |
