| First Author | Obst R | Year | 2000 |
| Journal | J Exp Med | Volume | 191 |
| Issue | 5 | Pages | 805-12 |
| PubMed ID | 10704462 | Mgi Jnum | J:263218 |
| Mgi Id | MGI:6188949 | Doi | 10.1084/jem.191.5.805 |
| Citation | Obst R, et al. (2000) The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules. J Exp Med 191(5):805-12 |
| abstractText | By analyzing T cell responses against foreign major histocompatibility complex (MHC) molecules loaded with peptide libraries and defined self- and viral peptides, we demonstrate a profound influence of self-MHC molecules on the repertoire of alloreactive T cells: the closer the foreign MHC molecule is related to the T cell's MHC, the higher is the proportion of peptide-specific, alloreactive ("allorestricted") T cells versus T cells recognizing the foreign MHC molecule without regard to the peptide in the groove. Thus, the peptide repertoire of alloreactive T cells must be influenced by self-MHC molecules during positive or negative thymic selection or peripheral survival, much like the repertoire of the self-restricted T cells. In consequence, allorestricted, peptide-specific T cells (that are of interest for clinical applications) are easier to obtain if T cells and target cells express related MHC molecules. |
