| Primary Identifier | MGI:1933736 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 107831 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including PDZ domain binding activity; lipopolysaccharide binding activity; and phosphatidylserine binding activity. Involved in several processes, including negative regulation of protein metabolic process; phagocytosis; and positive regulation of myoblast fusion. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including focal adhesion; phagocytic cup; and postsynaptic density. Is expressed in several structures, including brain; early conceptus; and reproductive system. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit spatial learning and memory deficits, enhanced long term potentiation, decreased long term depression, abnormal postsynaptic density morphology, and impaired synaptic plasticity in hippocampal neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
