| Primary Identifier | MGI:97599 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18754 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including 14-3-3 protein binding activity; actin monomer binding activity; and diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of actin filament polymerization; and positive regulation of fibroblast migration. Acts upstream of or within several processes, including cellular response to alcohol; positive regulation of cell communication; and regulation of secretion. Located in several cellular components, including cytosol; mitochondrion; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and submandibular gland primordium. Orthologous to human PRKCE (protein kinase C epsilon). PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
