| Primary Identifier | MGI:1861447 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 56642 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chromatin binding activity; protein kinase B binding activity; and titin binding activity. Involved in negative regulation of myoblast differentiation. Acts upstream of or within several processes, including negative regulation of myotube differentiation; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and skeletal muscle cell differentiation. Located in several cellular components, including PML body; sarcomere; and sarcoplasm. Part of euchromatin. Colocalizes with I band. Is expressed in skeletal musculature; somite; and tongue. Orthologous to human ANKRD2 (ankyrin repeat domain 2). PHENOTYPE: Mice homozygous for a null allele are viable, fertile and free of cardiac defects but exhibit altered inflammatory responses and are prone to skeletal muscle fiber-type switching of slow fibers toward a faster phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
