| First Author | Higuchi K | Year | 1993 |
| Journal | FEBS Lett | Volume | 317 |
| Issue | 3 | Pages | 207-10 |
| PubMed ID | 8381093 | Mgi Jnum | J:3936 |
| Mgi Id | MGI:52441 | Doi | 10.1016/0014-5793(93)81277-7 |
| Citation | Higuchi K, et al. (1993) Development of congenic strains of mice carrying amyloidogenic apolipoprotein A-II (Apoa2c). Apoa2c reduces the plasma level and the size of high density lipoprotein. FEBS Lett 317(3):207-10 |
| abstractText | A congenic strain of mice with amyloidogenic apolipoprotein A-II (Apoa2c) on the genetic background of the amyloidosis-resistant SAM-R/1 strain was produced by 12 generations of backcrossing. Genome mapping using endogenous murine leukemia proviral markers was done in the congenic strain, termed R1.P1-Apoa2c. We confirmed that only a small region surrounding the apoA-II gene on chromosome 1 was transferred from the genome of the donor SAM-P/1 strain. The level and particle size of plasma high density lipoprotein were decreased in R1.P1-Apoa2c mice compared to those in the progenitor SAM-R/1 mice. The function of apoA-II can be studied using this strain of mice. |
