Primary Identifier | MGI:2176526 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Ptpn11 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | ES cell line = G1 (Bayer Corp., unpublished). This appears to have been derived from an unspecified subline of 129. |
molecularNote | A neomycin resistance cassette replaced a genomic fragment containing exon 2 and flanking sequences. Western blot analysis on lyastes prepared from various tissues of heterozygous mice confirmed that protein levels were reduced by 40-50% in all tissue examined. |