Primary Identifier | MGI:106611 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 22671 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including GTP binding activity; GTPase activity; and protein self-association. Involved in several processes, including embryonic brain development; protein autoubiquitination; and response to hydroperoxide. Acts upstream of or within G1 to G0 transition involved in cell differentiation; positive regulation of glial cell differentiation; and positive regulation of neuron differentiation. Located in several cellular components, including cytoplasmic vesicle; nuclear body; and postsynaptic density. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human RNF112 (ring finger protein 112). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced dendritic spines, functional synapses and paired pulse facilitation. [provided by MGI curators] |