| First Author | Itoh K | Year | 1995 |
| Journal | Science | Volume | 270 |
| Issue | 5240 | Pages | 1369-72 |
| PubMed ID | 7481827 | Mgi Jnum | J:29839 |
| Mgi Id | MGI:77363 | Doi | 10.1126/science.270.5240.1369 |
| Citation | Itoh K, et al. (1995) Regulated expression of the neural cell adhesion molecule L1 by specific patterns of neural impulses. Science 270(5240):1369-72 |
| abstractText | Development of the mammalian nervous system is regulated by neural impulse activity, but the molecular mechanisms are not well understood. If cell recognition molecules [for example, L1 and the neural cell adhesion molecule (NCAM)] were influenced by specific patterns of impulse activity, cell-cell interactions controlling nervous system structure could be regulated by nervous system function at critical stages of development. Low-frequency electrical pulses delivered to mouse sensory neurons in culture (0.1 hertz for 5 days) down-regulated expression of L1 messenger RNA and protein (but not NCAM). Fasciculation of neurites, adhesion of neuroblastoma cells, and the number of Schwann cells on neurites was reduced after 0.1-hertz stimulation, but higher frequencies or stimulation after synaptogenesis were without effect. |
