| Type | MGI:General | Description | show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age signs increase in severity with age more rapidly than in hemizygous mice decrease in myelination and irregular axonal staining in the brain myelin degradation, nude axons and thinly myelinated axons in the presence of myelinolysis are seen in the optic nerve |
